Endocrine Abstracts

Background: Capecitabine and temozolomide (CAPTEM) is a common regimen for the treatment of metastatic, well-differentiated pancreatic neuroendocrine tumors (PNETs). However, it is unknown whether certain genomic profiles predict response to CAPTEM. PNETs often contain mutations in MEN1, ATRX, DAXX, and the PI3K/AKT/mTOR pathway. We sought to determine whether the mutational status of these genes may correlate with progression-free survival (PFS) on CAPTEM.<p clas...

Background: Currently, there are limited therapeutic options for patients with advanced midgut neuroendocrine tumors progressing on first-line somatostatin analog therapy.Methods: NETTER-1 is the first phase III, randomized trial evaluating 177Lu-DOTA0-Tyr3-Octreotate (Lutathera®) in patients with progressive, somatostatin receptor positive midgut NETs. 230 patients were randomized to receive Lutathera 7.4...